Lupus Anticoagulants (LA) are a type of antiphospholipid antibodies which attack the body’s own immune system and healthy cells. They target phospholipids of the cell membrane and are known to cause antiphosholipid syndrome (APS) leading to frequent and abnormal blood clots. This can lead to formation of clots in multiple body parts including arms, legs, heart, lungs, stomach and kidney. Various complications such as cardiovascular diseases, stroke, kidney failure and lung damage can arise as a result of APS depending upon the organ affected by the blood clot.
LA test is recommended if a person suffers from frequent blood clotting or multiple miscarriages.
Early diagnosis is crucial to prevent the severity of APS.
A false positive result may be observed in case of a patient receiving blood thinners in treatment.
The Lupus Anticoagulant Test is performed:
Lupus anticoagulants are antibodies produced against the body’s own cells. These are produced when the immune system mistakenly identifies the body’s own cells as foreign matter and are specifically targeted against phospholipids and related proteins on the cell membranes. As a result, lupus anticoagulants affect the blood clotting process (thrombosis) and increase the risk of formation of blood clots.
The name lupus anticoagulant is a misnomer.
Presence of lupus anticoagulants in blood is associated with increased risk of thrombosis (formation of blood clots) in blood vessels, leading to an increased risk of heart attack, stroke, pulmonary embolism, as well as recurring miscarriage. LA is one of the three primary antiphospholipid antibodies, the other two being Cardiolipin antibody and β-2-glycoprotein antibody. Presence of these individually or together increases the chances of thrombosis and antiphospholipid antibody syndrome (APS). Thrombosis is more common in people with LA.
Lupus anticoagulants may sometimes be present without developing symptoms of abnormal clotting.
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